血清CysC与尿NAG、RBP联合检测在2型糖尿病早期肾损伤中的应用
时间：2021-02-05 04:01:29 来源：达达文档网 本文已影响 人 
任风梅
[摘要] 目的 探讨血清血清胱抑素（CysC）与尿β-N-乙酰葡萄糖苷酶（NAG）、尿视黄醇结合蛋白（RBP）联合检测在2型糖尿病早期肾损伤中的应用。方法 选择2018年5月—2019年5月该院收治的47例2型糖尿病早期肾损伤患者作为研究组，选择同期该院收治的47例2型糖尿病患者作为对照组。对比两组患者血清CysC与尿液NAG、RBP水平。同时，对比单项血清CysC指标、尿液NAG、RBP指标与3项指标联合诊断2型糖尿病早期肾损伤的阳性率。结果 研究组血清CysC指标与尿液NAG、RBP指标均高于对照组（P<0.05）。3项指标联合诊断的阳性率95.74%高于单项血清CysC指标阳性率76.60%、尿液NAG阳性率74.47%与RBP阳性率76.60%（P<0.05）。结论 血清CysC与尿NAG、RBP联合检测2型糖尿病早期肾损伤效果可靠。
[关键词] 血清CysC;尿NAG;RBP;2型糖尿病;早期肾损伤
[中图分类号] R59 [文献标识码] A [文章编号] 1672-4062（2020）07（a）-0194-03
Application of Combined Detection of Serum CysC， Urine NAG and RBP in Early Renal Injury of Type 2 Diabetes
REN Feng-mei
Wucheng County Traditional Chinese Medicine Hospital， Wucheng， Shandong Province， 253300 China
[Abstract] Objective To explore the application of combined detection of serum cystatin （CysC）， urine β-N-acetylglucosidase （NAG） and urinary retinol binding protein （RBP） in early renal injury of type 2 diabetes. Methods From May 2018 to May 2019， 47 patients with type 2 diabetes and early kidney injury treated in the hospital were selected as the research group， and 47 patients with type 2 diabetes admitted in the hospital during the same period were selected as the control group. The serum CysC and urine NAG and RBP levels were compared between the two groups. At the same time， the positive rate of early diagnosis of kidney injury in type 2 diabetes was compared between the single serum CysC index， urine NAG， RBP index and three indexes. Results The serum CysC index and urine NAG and RBP indexes in the study group were higher than those in the control group（P<0.05）. The positive rate of the combined diagnosis of the three indicators was 95.74% higher than the single serum CysC indicator positive rate of 76.60%， urine NAG positive rate of 74.47% and RBP positive rate of 76.60%（P<0.05）. Conclusion The combination of serum CysC， urine NAG and RBP in the detection of early renal injury in type 2 diabetes is reliable.
[Key words] Serum CysC; Urine NAG; RBP; Type 2 diabetes; Early kidney injury
糖尿病腎病是2型糖尿病患者常见的并发症，具有起病隐匿、进展慢等特点，且早期肾损伤症状不具备典型性，甚至部分患者微量蛋白尿与肾小球滤过功能亢进持续多年也未觉察，致使病机延误[1]。传统诊断早期肾损伤的方法包括血尿素氮（BUN）与肌酐（Cr），但部分研究发现此类指标的敏感性较差[2]。有研究根据糖尿病早期肾损伤患者肾功能与结构的变化，发现新型标志物β-N-乙酰葡萄糖苷酶（NAG）、尿视黄醇结合蛋白（RBP）与血清胱抑素（CysC）对糖尿病肾病具有一定的诊断意义[3]。该研究回顾性分析2018年5月—2019年5月该院对47例2型糖尿病早期肾损伤患者的资料，将其血清CysC与尿NAG、RBP联合检测结果与单纯糖尿病患者进行对比，以期为完善2型糖尿病早期肾损伤患者的诊疗方案提供可靠的参考，现报道如下。
