超分子“印迹模板”药素）特征的中药药理学研究方法探索
时间：2021-04-22 08:03:19 来源：达达文档网 本文已影响 人 
[摘要] 该文在前文超分子化学对中医药理论特殊影响的基础上，进一步分析中药成分的自然本源，阐述中药与人体经络脏腑超分子“印迹模板”通道结构（证素）的“气析”作用，从自然界超分子 “印迹模板”自主作用的普遍规律层面揭示中药“药素”属性，揭示别于西药药理学的中药药理学研究应遵循的方法。中药药理学研究受中医药基础理论指导，是由经络脏腑与中药成分群的超分子主客体“气析”作用关系决定的，在这种基于“分子社会”与经络脏腑通道的“印迹模板”能否匹配性地产生“气析”作用的宏观规律特殊表达过程中，超分子化学自主作用贯穿始终。中药药理学受中医药理论指导，是基于中医药理论，能用超分子化学诠释。基于经典的原子间的化学键形成的单分子化学结构构效关系奠定西药药理学，基于“分子社会”弱键的超分子“印迹模板”（药素）则构筑中药药理学大厦。中药药理学是在西药药理学基础上发展的针对“分子社会”间的超分子药理学，宜采用宏观数理定量表征和微观定性分析双重研究方法。
[关键词] 中药；中药药理学；超分子药理学；药理学；中医药基础理论；超分子；物质基础；证素；药素；气析；气素；中医药现代化；经络脏腑；数理特征化；分子社会
[Abstract] The paper， based on the previous publication as special impact of Chinese medicine theories on supramolcular chemistry， aims to analyze the natural origination for the Chinese medicine and to explain the special impact of ″Qi chromatography″ reaction on ″imprinting templates″ in supramolcular host of human being with Chinese medicine， in order to reveal the CM′s properties of ″medical element″ with ″imprinting templates″ autonomisation generally took place in natural supramolecules， and also to discover that the CM′s pharmacology are satisfied with its own approaches different form western pharmacology.It was decided， for CM′s pharmacology guided by CM′s theories， to ″Qi chromatography″ relations between the CM′s ingredient groups and the meridian zang-fu viscera. The supramolcular chemistry played an all-through role in procession of making macro-regularities and special presentation on behavior of ″Qi chromatography″ impulse owning to the matching action of all kinds of ingredients on the meridian zang-fu viscera with similar ″imprinting templates″. The CM′s pharmacology were guided by CM′s theories， owing to its interpretation of supramolecular chemistry. The pharmacology was achieved to construct up completely on base of classical chemical single molecular bonds whereas the CM′s pharmacology be configured to big building by way of ″imprinting templates″ as multi-weak bonds among ″supramolecular society″. CM′s pharmacology was supramolcular pharmacology dealt with ″molecular society″ on the base of western pharmacology， and employed to double research approaches both math-physical quantitative representation on macroscope and qualitative analyses in microscope.
[Key words] Chinese medicine； pharmacology of Chinese medicine； supramolecular pharmacology； pharmacology； basic theory of Chinese medicine；supramolecules； material basement；syndromic element； medical element； Qi chromatography； Qi element； Chinese medicine modernization； meridian Zang-fu viscera；mathematization and physization； molecular society
